Delusional Disorder

European Psychiatric Review, 2011;4(2):89-92

Abstract

Delusional disorder (or persistent delusional disorder) is a psychotic disorder characterised by delusions, whereas other relevant psychopathological symptoms are missing. Its prevalence is estimated at approximately 0.18 % in the general population and at 2–3 % in patients with psychotic disorders. There seem to be no relevant gender differences, except that the onset of the disorder in females is later in life than in males. Delusional disorder is predominantly an illness of middle to late adult life. The diagnostic stability is very high. The disorder is chronic and the treatment more difficult than in other psychotic disorders. Co-morbidity with major depression is relatively frequent, but the delusional disorder is independent of the co-morbid disorder. In some patients, the disorder is a risk for criminal behaviour. Nevertheless, the majority of patients do not have significant deficits in social functioning and stay autarkic.
Keywords
Delusional disorder, persistent delusional disorder, paranoia, diagnosis, prevalence, prognosis, treatment
Disclosure The author has no conflicts of interest to declare
Received: October 01, 2011 Accepted November 22, 2011
Correspondence: Andreas Marneros, Klinik und Poliklinik für Psychiatrie, Psychotherapie und Psychosomatik, Martin-Luther-Universität Halle-Wittenberg, 06097 Halle, Germany. E: andreas.marneros@medizin.uni-halle.de

Delusional disorders (according to the Diagnostic and Statistical Manual of Mental Disorders [DSM]) or persistent delusional disorders (according to the International Classification of Diseases [ICD]) have succeeded the old concept of paranoia,1,2 which was the most central concept in psychiatry in the 19th century. The paranoia concept was very broad and unspecific, and hence, according to Emil Kraepelin,3 70–80 % of all mentally ill patients were diagnosed with paranoia. After Kraepelin’s reform of the concept at the end of the 19th and the beginning of the 20th century, it became much narrower and more specific, so that its frequency went down to approximately 1 %, which is compatible with the frequency estimated according to modern criteria. Because of the confusion regarding the term and the concept of paranoia, George Winokur4 suggested the term ‘delusional disorder’, meaning exactly the same as ‘paranoia’ after Kraepelin’s reform. In 1987, the DSM, third edition revised (DSM-III-R) and, a few years later, the ICD-10,5 adopted the term ‘delusional disorder’.

Although, as Berrios1 pointed out, the new term is not unproblematic, the linguistic adaptation was necessary because the term paranoia was used very unspecifically and unprofessionally. The term ‘paranoid’ was used, especially in English-speaking countries, instead of the term ‘paranoic’. But paranoid is not the same as paranoic: paranoic always refers to paranoia, but paranoid means ‘something similar to paranoia, which is not exactly paranoia’. Paranoid schizophrenia, for example, means a schizophrenia-type-like paranoia, but not exactly the same, because additional symptoms (schizophrenic symptoms) can be detected. Another example is ‘paranoid personality’, a term used to describe a personality exhibiting symptomatology like paranoia, but which is not exactly paranoia, due to the criteria of a personality disorder. The same applies to ‘paranoid organic psychosis’. So it can be said that a paranoid individual may be a patient, but is not necessarily one, whereas a paranoic person is always a patient – a patient with a mental disorder, namely paranoia or delusional disorder.2

Definition and Diagnosis
Delusional disorder (as well as paranoia) can be defined as a mental disorder characterised by wrong, unfounded or uncorrectable convictions having a priori evidence, whereas other mental and personality domains usually remain intact. Delusional disorders are usually monosymptomatic and monothematic. That means that the exhibited delusion is the only relevant psychopathological symptom and the topic of the delusion refers to only one aspect, for instance jealousy, love or persecution. The ICD-105 uses the term ‘persistent delusional disorder’ and the DSM, fourth edition (DSM-IV)6 the term ‘delusional disorder’. Both definitions are practically identical. The only relevant difference is the duration: the ICD-10 demands a duration of at least three months (see Table 1), whereas the DSM-IV demands a duration of only one month (see Table 2). However, this difference is only theoretical, as delusional disorder is usually persistent. The definition of delusional disorder proposed for the DSM, fifth edition (DSM-5)7 will most probably be the same as in the DSM-IV.

Apart from the above-mentioned specific delusional disorders, a plethora of phenomenological types, such as misidentification syndromes or culture-related syndromes, have been described. Many of these, however, are not autonomous and autochthonous delusional disorders, but a symptom of other major mental disorders such as schizophrenia, mood disorder or organic psychotic disorder.

References:
  1. Berrios GE, Historiographical prologue. In: Marneros A (ed), Persistent Delusional Disorders Myths and Realities, New York: Nova Science Publishers, 2011;
  2. Marneros A, Persistent Delusional Disorders. Myths and Realities, New York: Nova Science Publishers, 2011.
  3. Kraepelin E, Psychiatrie. Ein Lehrbuch für Studierende und Ärzte, eighth edition, Leipzig: Johann Ambrosius Barth, 1915.
  4. Winokur G, Delusional disorder (paranoia), Compr Psychiatry, 1977;18:511–21.
  5. ICD-10 Classification of Mental and Behavioural Disorders. Clinical Descriptions and Diagnostic Guidelines, Geneva: WHO, 1991.
  6. American Psychiatric Association, Diagnostic and Statistical Manual of Mental Disorders, fourth edition, Washington, DC: American Psychiatric Publishing, 1994.
  7. American Psychiatric Association, Diagnostic and Statistical Manual of Mental Disorders, fifth edition, 2010. Available at: www.dsm5.org/ProposedRevisions (accessed date 18 November 2011).
  8. Perälä J, Suvisaari J, Saarni SI, et al., Lifetime prevalence of psychotic and bipolar I disorders in a general population, Arch Gen Psychiatry, 2007;64:19–28.
  9. Wustmann T, Pillmann F, Friedemann J, et al., The clinical and sociodemographic profile of persistent delusional disorders, Psychopathology, 2010;submitted.
  10. Manschreck TC, Delusional disorder. In: Fujii DE, Ahmed I (eds), The Spectrum of Psychotic Disorders: Neurobiology, Etiology, and Pathogenesis, Cambridge: Cambridge University Press, 2007;116–33.
  11. Kendler KS, Demography of paranoid psychosis (delusional disorder): a review and comparison with schizophrenia and affective illness, Arch Gen Psychiatry, 1982;39:890–902.
  12. Wustmann T, Pillmann F, Marneros A, Gender-related features of persistent delusional disorders, Eur Arch Psychiatry Clin Neurosci, 2010;261:29–36.
  13. Salvatore P, Baldessarini RJ, Tohen M, et al., McLean-Harvard International First-Episode Project: two-year stability of DSM-IV diagnoses in 500 first-episode psychotic disorder patients, J Clin Psychiatry, 2009;70:458–66.
  14. Maina G, Albert U, Bada A, Bogetto F, Occurrence and clinical correlates of psychiatric comorbidity in delusional disorder, Eur Psychiatry, 2001;16:222–8.
  15. Grover S, Biswas P, Avasthi A, Delusional disorder: Study from North India, Psychiatry Clin Neurosci, 2007;61:462–70.
  16. Korner A, Lopez AG, Lauritzen L, et al., Delusional disorder in old age and the risk of developing dementia - a nationwide register-based study, Aging Ment Health, 2008;12:625–9.
  17. Leinonen E, Santala M, Hyotyla T, et al., Elderly patients with major depressive disorder and delusional disorder are at increased risk of subsequent dementia, Nord J Psychiatry, 2004;58:161–4.
  18. Munro A, Delusional Disorder. Paranoia and Related Illnesses, Cambridge: Cambridge University Press, 1999.
  19. Manschreck TC, Khan NL, Recent advances in the treatment of delusional disorder, Can J Psychiatry, 2006;51:114–9.